ISSN: 1300-0306
İndekslendiği Dizinler:
Index CopernicusEMBASE/Excerpta Medica
Scopus
Dil: Türkçe, ingilizce
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ORIGINAL RESEARCH ARTICLES |
Evaluation Of ınsulin Resistance ın Obese, Postmenopausal Women Using Tibolone Or Combined Oral Hormone Therapy
Semin FENKCİ, MD,a Veysel FENKCİ, MD,b Yurdaer SERMEZ, MDa
aDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Pamukkale University School of Medicine, DENİZLİbDepartment of Obstetrics and Gynecology, Afyon Kocatepe University School of Medicine, AFYON
Objective: To elucidate insulin sensitivity with clinical use of homeostasis model assessment in obese, postmenopausal women receiving tibolone or combined oral hormone therapy.
Material and Methods: In this cross-sectional study, 85 obese, postmenopausal women were enrolled. 25 women were receiving tibolone, 33 subjects were using oral estradiol (E2) (2 mg/day) + norethistheron acetate (NETA) (1 mg/day), and 27 subjects were not on treatment. Waist and hip circumferences, height, weight, blood pressure, serum estradiol, fasting insulin, glucose levels and lipid fractions were measured. Waist-hip ratio and body mass index were calculated. Homeostasis model assessment for insulin resistance and bioelectric impedance analyses for total body fat mass were used.
Results: The lowest waist, waist/hip ratio, systolic blood pressure measurements, and triglyceride level were observed in tibolone group. Women receiving tibolone had significantly lower fat mass and higher fat-free mass in comparison with women not on treatment. Homeostasis model assessment was significantly lower in both treatment groups compared to control group. Total body fat mass positively correlated both with fasting insulin and homeostasis model assessment, whereas it was correlated inversely with fat-free mass. There was a positive relationship between fat-free mass and estradiol.
Conclusions: Homeostasis model assessment, which can be used to evaluate insulin sensitivity quickly, revealed that tibolone and combined oral hormone therapy might have not any harmful effect on insulin sensitivity in obese, postmenopausal women who already have a tendency towards high insulin resistance.Keywords: Insulin resistance, tibolone, hormone therapyTurkiye Klinikleri J Gynecol Obst 2006, 16:39-44
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